abstract：:The incidence of oncofoetal antigens has been reported to be increased in patients with gynaecological cancers. In this study the incidence of CEA, AFP, and hCG (beta subunit) were studied in patients with adenocarcinoma of the ovary, adenocarcinoma of the cervix, and squamous-cell carcinoma of the cervix. Using a low...

journal_title：British journal of cancer

authors： Cauchi MN,Koh SH,Lim D,Hay DL

更新日期：1981-09-01 00:00:00

abstract：:A representative sample of 4657 adults greater than or equal to 45 years of age from the 5 main ethnic groups in Hawaii (Caucasians, Japanese, Chinese, Filipinos and Hawaiians) were interviewed during 1977-1979 regarding their diets. Quantitative food-consumption histories were obtained, from which average daily intak...

journal_title：British journal of cancer

authors： Kolonel LN,Hankin JH,Lee J,Chu SY,Nomura AM,Hinds MW

更新日期：1981-09-01 00:00:00

abstract：:The oestrogen receptor (RE) status of the primary tumour has been assessed in 466 of a consecutive series of 550 patients with primary operable breast cancer. All patients were followed up (without treatment) until the development of recurrence or metastases. Distant metastases have so far occurred in 124 patients and...

journal_title：British journal of cancer

authors： Campbell FC,Blamey RW,Elston CW,Nicholson RI,Griffiths K,Haybittle JL

更新日期：1981-09-01 00:00:00

abstract：:Two cell lines (2-10-1 and 8-10-2) derived by exposure to primary tracheal explants to MNNG in vitro were not tumorigenic in syngeneic F-344 rats or athymic BALB/c (nu/nu) mice at early passage, but became tumorigenic at late passage. These cell lines are therefore suited to study the expression of neoantigens during ...

journal_title：British journal of cancer

authors： Braslawsky GR,Steele V,Kennel SJ,Nettesheim P

更新日期：1981-08-01 00:00:00

abstract：:In a case-control study, we investigated 169 women aged 15-49 years with malignant melanoma notified to the Oxford and South Western cancer registries during the years 1971-1976, together with 507 matched controls. Data about medical, reproductive, drug and smoking histories were obtained both by reviewing general pra...

journal_title：British journal of cancer

authors： Adam SA,Sheaves JK,Wright NH,Mosser G,Harris RW,Vessey MP

更新日期：1981-07-01 00:00:00

abstract：:An apparently unique circulating common oncofoetal protein has been identified in rat small-bowel, colonic and pancreatic adenocarcinomas. The tumours were induced by ionizing radiation (small bowel), an alkyl hydrocarbon, 1,2-dimethylhydrazine (colon) and a polyaromatic hydrocarbon, 7,12-dimethylbenz[a]anthracene (pa...

journal_title：British journal of cancer

authors： Stevens RH,Cole DA,Cheng HF

更新日期：1981-06-01 00:00:00

abstract：:Follicular-phase (Day 11) plasma prolactin, and plasma and urinary oestrogen levels of 70 nulliparous nuns were compared with those of 80 of their sisters, of whom 62 were parous. The nuns and their nulliparous sisters did not differ significantly in their prolactin and oestrogen levels. No differences in plasma oestr...

journal_title：British journal of cancer

authors： Yu MC,Gerkins VR,Henderson BE,Brown JB,Pike MC

更新日期：1981-06-01 00:00:00

abstract：:The level of Gross cell-surface antigen (GCSAa) expression at the surface of murine retrovirus-infected fibroblasts was determined by quantitative absorption of the anti-GCSAa activity of a serum produced in syngeneic W/Fu rats immunized against (C58NT)D lymphoma, and tested in a cytotoxicity assay against E male G2 l...

journal_title：British journal of cancer

authors： Gerlier D,Gisselbrecht S,Guillemain B,Doré JF

更新日期：1981-05-01 00:00:00

abstract：:Immunofluorescent assessment of hormone receptors in melanocytic tumours is quite feasible without loss of diagnostic material, in contrast to the impracticability of quantitative biochemical assays. Using this method, oestrogen receptors were demonstrated in 4/6, and progesterone receptors in 3/5 patients with metast...

journal_title：British journal of cancer

authors： Thompson AJ,Cook MG,Gill PG

更新日期：1981-05-01 00:00:00

abstract：:Maturation of monocytes into macrophages in vitro has been assayed by a quantitative microtitre assay in patients with squamous-cell carcinoma of the lung. Monocyte maturation in autologous serum was significantly depressed in patients with both limited and extensive disease compared with normal controls, patients wit...

journal_title：British journal of cancer

authors： Dent RG,Cole P

更新日期：1981-04-01 00:00:00

abstract：:The sera of 80 newly diagnosed lung-cancer patients have been examined for immune complexes and autoantibodies. Control subjects consisted of 20 bronchitic patients and 150 normal blood donors. Immune-complex measurements used 4 established and sensitive techniques (Raji cell assay, fluid and solid-phase C1q assays an...

journal_title：British journal of cancer

authors： Guy K,Di Mario U,Irvine WJ,Hunter AM,Hadley A,Horne NW

更新日期：1981-03-01 00:00:00

abstract：:An antigen common to human sarcomas, S3, has been further characterized. It is antigenically distinct from human blood-group substances A and B and from heterophile antigens such as Forssman, infectious mononucleosis and serum sickness antigens. Whilst S3 antigen preparations may contain small amounts of CEA and AFP t...

journal_title：British journal of cancer

authors： Sethi JK,Hirshaut Y

更新日期：1981-03-01 00:00:00

abstract：:A retrospective case-control study of 200 patients with head and neck cancer, and 200 controls matched for age and sex, confirmed the importance of tobacco and alcohol consumption in the aetiology of malignant tumours of the upper gastrointestinal and upper respiratory tracts. A male-female ratio of 3:1 was found, and...

journal_title：British journal of cancer

authors： Herity B,Moriarty M,Bourke GJ,Daly L

更新日期：1981-02-01 00:00:00

abstract：:Monoclonal antibodies to carcinoembryonic antigen (CEA) promise improved specificity for the measurement of this widely expressed human cancer antigen. A mouse monoclonal antibody binds weakly to CEA in perchloric acid extracts of tumour but strongly to CEA similarly isolated from serum, and its spectrum of cancer det...

journal_title：British journal of cancer

authors： Rogers GT,Rawlins GA,Bagshawe KD

更新日期：1981-01-01 00:00:00

abstract：:The relationship between oestrogen receptor (RE) content of primary breast cancer and subsequent prognosis was examined with regard to nodal status. It was found that, within a particular nodal group, patients with tumours containing fully functional RE experienced a longer disease-free interval than those with RE- di...

journal_title：British journal of cancer

authors： Leake RE,Laing L,McArdle C,Smith DC

更新日期：1981-01-01 00:00:00

abstract：:I have studied the effects on growth of two tumours in mice and on host toxicity, of combining Misonidazole (MISO) or Metronidazole (METRO) with Methotrexate (MTX)-5-fluorouracil (FU) or Adriamycin (ADR). The nitroimidazoles alone had no effect on the growth of either tumour, but MISO (1 mg/g) led to a small increase ...

journal_title：British journal of cancer

authors： Tannock IF

更新日期：1980-12-01 00:00:00

abstract：:The effect of 6 putative prognostic factors on survival was studied in patients with Stages III and IV malignant teratoma of the testis. Differences between survival curves were tested for statistical significance. A diameter greater than 5 cm in the largest tumour mass, and greater than 8 pulmonary metastases were ad...

journal_title：British journal of cancer

authors： Germa-Lluch JR,Begent RH,Bagshawe KD

更新日期：1980-12-01 00:00:00

abstract：:Experiments were conducted to determine whether bladder cancer would develop in primates (Papio sp.) infected with S. haematobium and concurrently exposed to low initiating doses of the bladder carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). To control for the systemic effects of schistosomiasis, 5 baboons wer...

journal_title：British journal of cancer

authors： Hicks RM,James C,Webbe G

更新日期：1980-11-01 00:00:00

abstract：:The effects of local tumour radiation over the dose range 7.5-30 Gy on the growth and cell kinetics of rat hepatoma H-4-II-E have been investigated. A plot of growth delays against log surviving fraction was linear below a fraction of 0.03, but failed to extrapolate to the origin. Following a single dose of 15 Gy to t...

journal_title：British journal of cancer

authors： Rowley R,Hopkins HA,Betsill WL Jr,Ritenour ER,Looney WB

更新日期：1980-10-01 00:00:00

abstract：:In a longitudinal study of the evolution of serum beta 2-microglobulin (beta 2-m) levels in 37 patients with myelomatosis, those patients with a level of < 4 mg/l at first presentation had a median survival of 46 months, whereas those with an initial level of > mg/l had a median survival of 15 months. THe beta 2-m app...

journal_title：British journal of cancer

authors： Norfolk D,Child JA,Cooper EH,Kerruish S,Ward AM

更新日期：1980-10-01 00:00:00

abstract：:Clinical-pathologic-genetic studies were performed on 3 kindreds showing the familial atypical multiple mole-melanoma syndrome (FAMMM). Findings showed vertical transmission, including father-to-son, of cutaneous malignant melanoma and/or FAMMM moles with no sex predilection. A broad spectrum of clinical signs charact...

journal_title：British journal of cancer

authors： Lynch HT,Fusaro RM,Pester J,Lynch JF

更新日期：1980-07-01 00:00:00

abstract：:Differences were seen in the ability of 2 strains of C. parvum to augment cytotoxicity attributable to NK cells towards a rat lymphoma. Furthermore, 2 batches of the same strain of C. parvum prepared by different methods also differed in their ability to augment cytotoxicity. Other factors influencing cytotoxicity wer...

journal_title：British journal of cancer

authors： Flexman JP,Shellam GR

更新日期：1980-07-01 00:00:00

abstract：:Analysis of data from 1434 children with primary renal tumours revealed 57 who developed bone metastases. Of these, 54 were initially recorded as nephroblastoma. Fifty-two of the 57 cases were reviewed histologically, and only 18 were found to be Wilms' tumours. Twenty-three were classified as "Bone-Metastasizing Rena...

journal_title：British journal of cancer

authors： Marsden HB,Lennox EL,Lawler W,Kinnier-Wilson LM

更新日期：1980-06-01 00:00:00

abstract：:Survival and proliferation of cell cultures from human anaplastic astrocytomas were shown to be enhanced by glucocorticoids with an optimal concentration of approximately 2.5 x 10(-5)M (10 micrograms/ml). The stimulation of proliferation was only observed in a clonal growth assay and was reversed as the size of indivi...

journal_title：British journal of cancer

authors： Freshney RI,Sherry A,Hassanzadah M,Freshney M,Crilly P,Morgan D

更新日期：1980-06-01 00:00:00

abstract：:Immunoreactive and bioassayable plasma fibronectin (opsonic α(2) surface-binding (SB) glycoprotein) was measured during experimental Sarcoma-180 tumour growth in mice. Male C57BL/6 mice were challenged s.c. with 2 × 10(6) viable Sarcoma-180 tumour cells and evaluated sequentially in parallel with saline-injected contr...

journal_title：British journal of cancer

authors： Saba TM,Gregory TJ,Blumenstock FA

更新日期：1980-06-01 00:00:00

abstract：:The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice. Polyamine levels and the numbers of tumour-cell colonies in the lungs were determined at weekly intervals. Putrescine levels in both erythrocytes and pla...

journal_title：British journal of cancer

authors： Takami H,Nishioka K

更新日期：1980-05-01 00:00:00

abstract：:The influence of human serum albumin (HA) on the biological effects of 13 chemotherapeutic agents was studied in vitro in the human leukaemia cell line MOLT-3. On the basis of changes in biological activity influenced by HA, these drugs may be divided into three types. Type I agents include cis-diamminedichloroplatinu...

journal_title：British journal of cancer

authors： Takahashi I,Ohnuma T,Kavy S,Bhardwaj S,Holland JF

更新日期：1980-04-01 00:00:00

abstract：:I.p. administration at several dose levels over periods of up to 12 weeks, or continuous i.v. infusion of high doses of misonidazole (MISO) for 15 h, produced no significant change in peripheral nerve conduction velocity (NCV) and did not prevent the normal increase in NCV as the animals matured from 12 to 24 weeks of...

journal_title：British journal of cancer

authors： Conroy PJ,Von Burg R,Penney DP,Passalacqua W,Sutherland RM

更新日期：1980-04-01 00:00:00

abstract：:The murine dose of i.v. C. parvum (466 microgram) was compared with a single, low, human-equivalent dose of 70 microgram and with repeated weekly low doses. All treatments increased the antibody titre against C. parvum (CP). However, repeated doses stimulated a much higher titre than single doses. In all treated anima...

journal_title：British journal of cancer

authors： Mitcheson HD,Sadler TE,Castro JE

更新日期：1980-03-01 00:00:00

abstract：:Tumour-associated prostaglandin-like material, assessed by bioassay, has been examined in 37 patients with primary and metastatic squamous carcinomas of the head and neck, previously treated by radiotherapy and chemotherapy followed by radical surgery. High amounts of prostaglandin-like material were extracted from tu...

journal_title：British journal of cancer

authors： Bennett A,Carter RL,Stamford IF,Tanner NS

更新日期：1980-02-01 00:00:00

abstract：:Both misonidazole (MISO) and hyperthermia are known to enhance the radiation response of hypoxic cells, and to be selectively cytotoxic against cells in a hypoxic and acidic environment. The ability of these conditions to modify the effect of irradiation and their individual relationship was studied in a C3H mammary c...

journal_title：British journal of cancer

authors： Overgaard J

更新日期：1980-01-01 00:00:00

abstract：:Axillary lymph nodes draining mammary carcinoma showed an alteration of both micro-architectue and lymphocyte subpopulations. Lymph nodes with a normal or increased T and/or B lymphocyte compartment (assessed by histology) had a low incidence of nodal tumour spread, whilst hypocellularity of the T- or B-lymphocyte-dep...

journal_title：British journal of cancer

authors： Eremin O,Roberts P,Plumb D,Stephens JP

更新日期：1980-01-01 00:00:00

abstract：:Using the DMBA-induced mammary tumour as a model, the effect of hormone manipulation on steroid sulphurylation and on oxidative and reductive metabolism has been investigated. Oestradiol-17 beta, or oestradiol-17 beta + progesterone, administered to oophorectomized animals, had no effect on adenosine-3'-phosphate-5'-p...

journal_title：British journal of cancer

authors： Li K,Chandra DP,Pewnim T,Foo T,Adams JB

更新日期：1980-01-01 00:00:00

abstract：:Fluorescence polarization measurement during the progress of fluorochromasia has been used to study the response of human lymphocytes to phytohaemagglutinin (PHA) and to tumour-associated antigens, as a basis for the detection of malignant disease. Polarization (P) values of both stimulated and unstimulated lymphocyte...

journal_title：British journal of cancer

authors： Balding P,Light PA,Preece AW

更新日期：1980-01-01 00:00:00

abstract：:Eleven patients with measurable subcutaneous or pulmonary metastases were selected for a study of the effectiveness of the radiosensitizer misonidazole (MIS). Evaluable data were obtained in 6 patients and radiosensitization demonstrated in 5. Patients were irradiated either before or after MIS, and each patient acted...

journal_title：British journal of cancer

authors： Ash DV,Peckham MJ,Steel GG

更新日期：1979-12-01 00:00:00

abstract：:The relationship between melanoma incidence and latitude was investigated in North American and Europe, using the data collected by 43 population-based cancer registries. In North America melanoma incidence increased with decreasing latitude, supporting the role of UV light in the induction of melanoma. Within England...

journal_title：British journal of cancer

authors： Crombie IK

更新日期：1979-11-01 00:00:00

abstract：:Human pancreatic exocrine adenocarcinoma cells established in tissue culture expressed both HLA and beta 2-microglobulin (beta 2M). Plasma-membrane components of this pancreatic cancer cell line were purified from plasma membrane fractions enriched by sucrose density-gradient centrifugation, using immunoaffinity chrom...

journal_title：British journal of cancer

authors： Påhlman S,Ljungstedt-Poahlman I,Sanderson A,Ward PJ,Grant A,Hermon-Taylor J

更新日期：1979-11-01 00:00:00

abstract：:High-mol.-wt levan injected locally inhibits the growth of Lewis lung carcinoma in C57BL mice. The inhibition is dependent on the number of tumour cells injected and on the dose of levan. The inhibition decreases tumour incidence and size as well as prolonging survival. The polysaccharide is most effective when inject...

journal_title：British journal of cancer

authors： Leibovici J,Borit A,Sandbank U,Wolman M

更新日期：1979-10-01 00:00:00

abstract：:Human peripheral-blood mononuclear cells, separated by Isopaque-Ficoll flotation and E-rosette formation, were tested by the fluorescein fluorescence polarization method of Cercek & Cercek (the SCM test). The response to stimulation with PHA or cancer tissue leads to a decreased polarization value TP). The responding ...

journal_title：British journal of cancer

authors： Orjasaeter H,Jordfald G,Svendsen I

更新日期：1979-10-01 00:00:00

abstract：:Geographical correlations between standardized, mortality ratios (SMRs) of cancers and consumption of different types of alcoholic beverages (saké synthetic saké, shochu, beer, wine, and whisky), of cigarettes, and urbanization were examined for all 46 prefectures in Japan. Suggestive correlations were observed betwee...

journal_title：British journal of cancer

authors： Kono S,Ikeda M

更新日期：1979-09-01 00:00:00